backpropagation artificial neural networks (Eigenvector Research Inc)
Structured Review
![Exploratory analysis by PCA comparing COVID-19 patients (all severity groups; inclusive of all collected timepoints). ( a ) ANOVA test for each TCR vb family ( p < 0.05 is considered statistically significant [circled]). ( b ) PCA performed using the TCR vb families with p < 0.05. Clustering separation between the groups can be observed. ( c ) Key loadings (features) on PC1. ( d ) Key loadings on PC2. ( e ) Classification modelling using <t>backpropagation</t> artificial neural networks <t>(ANNs);</t> the model shows good separation for MA and IP critical, and lower performance is noted for IP severe followed by IP moderate (correct responses shaded in yellow).](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_7081/pmc11507081/pmc11507081__diagnostics-14-02330-g002.jpg)
Backpropagation Artificial Neural Networks, supplied by Eigenvector Research Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Images
1) Product Images from "Investigation of Long-Term CD4+ T Cell Receptor Repertoire Changes Following SARS-CoV-2 Infection in Patients with Different Severities of Disease"
Article Title: Investigation of Long-Term CD4+ T Cell Receptor Repertoire Changes Following SARS-CoV-2 Infection in Patients with Different Severities of Disease
Journal: Diagnostics
doi: 10.3390/diagnostics14202330
Figure Legend Snippet: Exploratory analysis by PCA comparing COVID-19 patients (all severity groups; inclusive of all collected timepoints). ( a ) ANOVA test for each TCR vb family ( p < 0.05 is considered statistically significant [circled]). ( b ) PCA performed using the TCR vb families with p < 0.05. Clustering separation between the groups can be observed. ( c ) Key loadings (features) on PC1. ( d ) Key loadings on PC2. ( e ) Classification modelling using backpropagation artificial neural networks (ANNs); the model shows good separation for MA and IP critical, and lower performance is noted for IP severe followed by IP moderate (correct responses shaded in yellow).
Techniques Used:
Figure Legend Snippet: Exploratory analysis by PCA comparing COVID-19 IP severity groups (all timepoints). ( a ) ANOVA test for each TCR vb family ( p < 0.05 is considered statistically significant [circled]). ( b ) PCA performed using the TCR vb families with p < 0.05. Good clustering separation between the groups can be observed. ( c ) Key loadings (features) on PC1. ( d ) Classification modelling using backpropagation artificial neural networks (ANNs); good classification between IP severity groups can be obtained (correct responses shaded in yellow), thus, given the TCR VB family CD4+ percentage, the model can predict if the patient is moderate, severe, or critical. ( e ) ROC analysis curves; performance characteristics indicate outstanding discrimination for classification of moderate and critical disease IPs, and excellent discrimination for severe disease IPs, sensitivity (blue), specificity (red).
Techniques Used: